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Scientists Develop Gel That Can Regrow Tooth Enamel

Once tooth enamel breaks or wears away it’s over – it doesn’t grow back. That’s why dentists have to plug in the gaps with artificial fillings. But now, a team of scientists from China’s Zhejiang University and Jiujiang Research Institute says it has finally figured out how to regrow tooth enamel, a development that could totally upend dental care. The team developed a gel that has been found to help mouse teeth regrow enamel within 48 hours. The research has been published in the journal Science Advances.

parts of the tooth

 What exactly is enamel and why can’t it regrow? It is a mineralized substance with a highly complicated structure that covers the surface of teeth. The structure is made up of enamel rods interwoven with inter-rods in a fish scale pattern which makes it the hardest tissue in the human body. It is initially formed biologically but once mature it becomes acellular, meaning it becomes devoid of the ability to self-repair. This is why cavities (tooth decay) are one of the most prevalent chronic diseases in humans.

 Electron microscope images of human tooth enamel that has been repaired for six, 12 and 48 hours. The blue area is the native enamel; the green is the repaired enamel
Electron microscope images of human tooth enamel that has been repaired for six, 12 and 48 hours. The blue area is the native enamel; the green is the repaired enamel. Photograph: Zhejiang University/Science Advances

Enamel is so complex that its structure has yet to be duplicated correctly artificially. Resins, ceramics and amalgam fillings can mend the problem but they are not a forever fix. The fact that they are made of foreign materials means they can’t achieve a permanent repair. The new gel made by the Chinese scientists is different because it is made of the same material as enamel. It is made by mixing calcium and phosphate ions – both minerals which are found in enamel – with the chemical called triethylamine in an alcohol solution. For now, the gel is only a promising sign that regenerative dentistry could someday heal tooth decay. There’s a long way to go before the gel can be used in human medicine because it is still too thin. Natural-grown enamel is 400 times thicker than that grown with assistance from the new gel. Until they can solve that piece of the puzzle, fillings will continue to be the more useful option for people with cavities for the foreseeable future.The scientists are currently continuing the testing on mice and plan to eventually test the gel on people, tracking how the new enamel holds up as they go about their day, eating, drinking, and chewing.


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